The monarch is aiming to deliver her speech, which sets out the Government’s policies and proposed legislation for the new session on Tuesday.
But Her Majesty, who has been experiencing mobility issues, will confirm her attendance on the day.
The 96-year-old has cut back on several engagements in recent months.
The Queen has opened Parliament annually throughout her reign, missing it only twice in 1959 and 1963 – when she was pregnant.
If she is unable to attend this year, it is likely Prince Charles will step in.
It comes after Buckingham Palace confirmed the Queen will not attend any garden parties this year.
Garden parties will be staged from next week for the first time in three years.
They are important events in the royal calendar as those who have served their country or communities are invited to the monarch’s home.
A spokesman said: “Her Majesty The Queen will be represented by other members of the royal family at this year’s garden parties, with details on attendance to be confirmed in due course.”
The Queen attended a service commemorating the life of Prince Philip in March with senior royals and a congregation of hundreds.
She reached her Platinum Jubilee in February, overcame a bout of Covid after testing positive that month, and celebrated her 96th birthday privately on April 21 at her Sandringham estate.
Last October, the Queen spent a night in hospital.
She spent the following three months under doctors’ orders to only conduct light duties and missed a number of prominent events.
The Queen, Prince Charles and Camilla at the State Opening of Parliament in 2019
Victoria Jones
The Queen
Dominic Lipinski