The third-in-line to the throne, who turns nine next month, organised a cake sale during lockdown to raise money for Tusk.
George's dad, Prince William, is patron of the conservation charity and has travelled abroad to visit projects it supports in the past.
Before the charity existed, up to 100,000 elephants a year were killed by poachers in the illegal ivory trade.
For 30 years, Tusk has supported under-resourced local organisations to help them protect animals and their habitats.
Chief Executive Officer of Tusk Charlie Mayhew told GB News: "Prince George very sweetly did a little cake sale to raise money for Tusk during lockdown and wrote a very sweet card about it, clearly demonstrating his concern for Africa's wildlife."
In 2020, George shared his passion for animals with Sir David Attenborough alongside his siblings, Princess Charlotte and Prince Louis.
The veteran broadcaster gave George a fossilised giant shark's tooth when they met at Kensington Palace and the young royal asked him which animal he thinks would become extinct next.
Sir David told him: "Well let's hope there won't be any, because there are a lot of things we can do when animals are in danger of extinction.
"We can protect them."
George is the fourth generation of the Royal Family to champion environmental causes.
His dad William, who turns 40 today, frequently sends WhatsApp messages to Tusk's CEO "to discuss an issue that has occurred to him", according to the Daily Mail.
Mr Mayhew said the Duke's Patronage has led to more money for the charity and more publicity to promote the wider conservation movement.
He said William uses "his patronage of Tusk as a means to get some very powerful messages across".
In 1970 William's dad, Prince Charles, gave his first major speech on the environment and believes that "economic and social development will best succeed when it works in harmony, rather than in conflict, with Nature".
Charles will attend the Commonwealth Heads of Government Meeting in Rwanda this week and is expected to spend a day focusing on Climate, Health, and the Private Sector.
The Prince will meet business owners from across the Commonwealth and discuss his Sustainable Markets Initiative, which aims to boost economies by harnessing the power of nature combined with the innovation and resources of private companies.
Charles' late dad, Prince Philip, had a lifelong commitment to wildlife conservation and became President of the World Wildlife Fund's UK Branch in 1961.
Tusk's CEO hopes William will take his children, George, Princess Charlotte, and Prince Louis to Africa one day, so they can experience first-hand the work being done to protect wildlife for future generations.
Prince George with Prince William during the Queen's Platinum Jubilee celebrations
Chris Jackson
Prince George, Princess Charlotte and Prince Louis with Prince William for their Father's Day photograph
Kensington Palace